MX1 and PDE9A

Data Source:
BioGRID (proximity labelling technology)

		MX1	PDE9A
Description		MX dynamin like GTPase 1	phosphodiesterase 9A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Dendritic Spine Head Perinuclear Region Of Cytoplasm Presynapse Postsynaptic Endocytic Zone Membrane	Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Ruffle Membrane Sarcolemma Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Synapse Structure Or Activity Defense Response To Virus Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP-mediated Signaling CGMP Metabolic Process CGMP Catabolic Process
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	cGMP effects
Drugs			Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		41 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623	36 interacting genes: BAG3 C9orf106 CDC37 CLK1 CRY2 CYSRT1 GORASP2 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5
Entrez ID		4599	5152
HPRD ID		00919	09115
Ensembl ID		ENSG00000157601	ENSG00000160191
Uniprot IDs		P20591	A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083
PDB IDs		3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM	2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N
Enriched GO Terms of Interacting Partners?
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