MUC5AC and GALNT12

Data Source:
BioGRID (enzymatic study)

		MUC5AC	GALNT12
Description		mucin 5AC, oligomeric mucus/gel-forming	polypeptide N-acetylgalactosaminyltransferase 12
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Mucus Layer	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway O-glycan Processing Phosphatidylinositol-mediated Signaling	O-glycan Processing Protein Phosphopantetheinylation
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (adult onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Idiopathic pulmonary fibrosis ( 24429156)	Asthma ( 31959851) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		2 interacting genes: GALNT12 GALNT14	16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC
Entrez ID		4586	79695
HPRD ID			13561
Ensembl ID		ENSG00000215182	ENSG00000119514
Uniprot IDs		P98088	Q8IXK2
PDB IDs		5AJN 5AJO 5AJP	6PXU
Enriched GO Terms of Interacting Partners?
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