MSX1 and MED19

Data Source:
BioGRID (two hybrid)

		MSX1	MED19
Description		msh homeobox 1	mediator complex subunit 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Coregulator Activity Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Negative Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of BMP Signaling Pathway Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Stem Cell Differentiation Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Roof Of Mouth Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development BMP Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth agenesis; Hypodontia Tooth and nail syndrome; Witkop syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Breast cancer and/or colorectal cancer ( 29698419) Congenital heart disease ( 23708191) Electrocardiographic conduction measures ( 19389651) Nonsyndromic cleft lip with cleft palate ( 28232668)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Reticulocyte count ( 32888494) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		25 interacting genes: CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RBPMS RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TLE5 TP53	19 interacting genes: APP DCK DHRS7B DTX2 GRB2 HLCS KANK2 MED17 MED27 MED31 MED8 MED9 MSX1 NEDD9 NFKBIA OSTF1 RADIL RIPPLY1 ZNF76
Entrez ID		4487	219541
HPRD ID		00866	17477
Ensembl ID		ENSG00000163132	ENSG00000156603
Uniprot IDs		P28360	A0JLT2
PDB IDs
Enriched GO Terms of Interacting Partners?
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