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ASS1 and PTPN1
Data Source:
BioGRID
(two hybrid)
ASS1
PTPN1
Description
argininosuccinate synthase 1
protein tyrosine phosphatase non-receptor type 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Lysosome
Endoplasmic Reticulum
Cytosol
Perikaryon
Extracellular Exosome
Cell Body Fiber
Mitochondrial Matrix
Early Endosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Mitochondrial Crista
Protein-containing Complex
Sorting Endosome
Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Molecular Function
RNA Binding
Argininosuccinate Synthase Activity
Protein Binding
ATP Binding
Toxic Substance Binding
Amino Acid Binding
Identical Protein Binding
RNA Binding
Protein Tyrosine Phosphatase Activity
Insulin Receptor Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Cadherin Binding
Ephrin Receptor Binding
Protein Phosphatase 2A Binding
Biological Process
Urea Cycle
Citrulline Metabolic Process
Argininosuccinate Metabolic Process
Kidney Development
Liver Development
Arginine Biosynthetic Process
Aspartate Metabolic Process
Acute-phase Response
Midgut Development
Aging
Response To Nutrient
Circadian Rhythm
Response To Zinc Ion
Response To Mycotoxin
Response To Estradiol
Response To Drug
Positive Regulation Of Nitric Oxide Biosynthetic Process
Response To Growth Hormone
Diaphragm Development
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Ammonium Ion
Cellular Response To CAMP
Cellular Response To Interferon-gamma
Cellular Response To Tumor Necrosis Factor
Cellular Response To Glucagon Stimulus
Cellular Response To Oleic Acid
Cellular Response To Amine Stimulus
Cellular Response To Laminar Fluid Shear Stress
Cellular Response To Dexamethasone Stimulus
Negative Regulation Of Leukocyte Cell-cell Adhesion
Protein Dephosphorylation
Activation Of JUN Kinase Activity
Insulin Receptor Signaling Pathway
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Endocytosis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Actin Cytoskeleton Reorganization
Regulation Of Intracellular Protein Transport
Cellular Response To Unfolded Protein
Peptidyl-tyrosine Dephosphorylation
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
IRE1-mediated Unfolded Protein Response
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Positive Regulation Of Receptor Catabolic Process
Pathways
Urea cycle
Integrin signaling
Negative regulation of MET activity
Regulation of IFNG signaling
PTK6 Down-Regulation
MECP2 regulates neuronal receptors and channels
Regulation of IFNA signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Arginine
Aspartic acid
Aspartic acid
Citrulline
Citrulline
ATP
3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acid
5-(2-Fluoro-5-{(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]-1-propen-1-yl}phenyl)-1,2-oxazole-3-carboxylic acid
2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide
[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,
{4-[(2S)-2-({[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonic acid
Compound 19
3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acid
2-(Oxalyl-Amino)-Benzoic Acid
{[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)
Novo Nordisk a/S Compound
N-(Bromoacetyl)-beta-alanyl-N-(2-{4-[(carboxycarbonyl)amino]phenyl}ethyl)-L-serinamide
7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
PNU177836
2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
(4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid
4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid
L-cysteic acid
2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid
Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
2-[{4-[(2S)-2-{[(Allyloxy)carbonyl]amino}-3-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}amino)-3-oxopropyl]phenyl}(carboxycarbonyl)amino]benzoic acid
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide
[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
N-(3-Carboxypropanoyl)-L-phenylalanyl-3-carboxy-O-(carboxymethyl)-N-pentyl-L-tyrosinamide
1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID
ISIS 113715
Trodusquemine
Ertiprotafib
4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID
[(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid
4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID
2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
[(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid
5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID
ISOTHIAZOLIDINONE ANALOG
4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
p-Benzoyl-L-phenylalanine
6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
Diseases
Citrullinemia (CTLN)
GWAS
Basophil count (
32888494
)
Colorectal cancer (
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Intraocular pressure (
29617998
29785010
31959993
30054594
)
Lymphocyte percentage of white cells (
32888494
)
Thyroid stimulating hormone levels (
30843173
)
Vitiligo (
27723757
)
Interacting Genes
15 interacting genes:
AKTIP
APP
ARAF
ASCC2
ELN
JAK2
LINC01554
MLH1
MT2A
PTPN1
SLC13A1
SUMO2
TERF1
TERF2
USP4
66 interacting genes:
ACTN1
AGR3
AKT1
AQP6
ASS1
BCAR1
BCAS3
BCR
CAPN2
CASC3
CASZ1
CAV1
CCL5
CDH13
CDH2
CDK1
CLK1
CLK2
COP1
CRK
CSNK2A1
CSNK2A2
CTNNB1
DIRAS3
EGFR
ELOVL4
ESR1
FGFR1
GHR
GLRX
GRB2
GSK3B
IGF1R
INSR
IRS1
JAK2
KLK7
LAT
LRATD2
LTK
MAPK1
MRC2
NFKBIA
NTRK1
NTRK2
NTRK3
PDGFRB
PIAS1
PIGP
PIN1
RHOBTB2
RRAS2
SNAI1
SRC
STAM2
STAT3
STAT5A
STAT5B
THRSP
TIMMDC1
TMEM31
TMEM41A
TMEM86B
TRPV6
TYK2
VPS45
Entrez ID
445
5770
HPRD ID
04590
01477
Ensembl ID
ENSG00000130707
ENSG00000196396
Uniprot IDs
P00966
Q5T6L4
A8K3M3
B4DSN5
P18031
PDB IDs
2NZ2
1A5Y
1AAX
1BZC
1BZH
1BZJ
1C83
1C84
1C85
1C86
1C87
1C88
1ECV
1EEN
1EEO
1G1F
1G1G
1G1H
1G7F
1G7G
1GFY
1I57
1JF7
1KAK
1KAV
1L8G
1LQF
1NL9
1NNY
1NO6
1NWE
1NWL
1NZ7
1OEM
1OEO
1OES
1OET
1OEU
1OEV
1ONY
1ONZ
1PA1
1PH0
1PTT
1PTU
1PTV
1PTY
1PXH
1PYN
1Q1M
1Q6J
1Q6M
1Q6N
1Q6P
1Q6S
1Q6T
1QXK
1SUG
1T48
1T49
1T4J
1WAX
1XBO
2AZR
2B07
2B4S
2BGD
2BGE
2CM2
2CM3
2CM7
2CM8
2CMA
2CMB
2CMC
2CNE
2CNF
2CNG
2CNH
2CNI
2F6F
2F6T
2F6V
2F6W
2F6Y
2F6Z
2F70
2F71
2FJM
2FJN
2H4G
2H4K
2HB1
2HNP
2HNQ
2NT7
2NTA
2QBP
2QBQ
2QBR
2QBS
2VEU
2VEV
2VEW
2VEX
2VEY
2ZMM
2ZN7
3A5J
3A5K
3CWE
3D9C
3EAX
3EB1
3EU0
3I7Z
3I80
3QKP
3QKQ
3SME
3ZMP
3ZMQ
3ZV2
4BJO
4I8N
4QAH
4QAP
4QBE
4QBW
4Y14
4ZRT
5K9V
5K9W
5KA0
5KA1
5KA2
5KA3
5KA4
5KA7
5KA8
5KA9
5KAA
5KAB
5KAC
5KAD
5QDE
5QDF
5QDG
5QDH
5QDI
5QDJ
5QDK
5QDL
5QDM
5QDN
5QDO
5QDP
5QDQ
5QDR
5QDS
5QDT
5QDU
5QDV
5QDW
5QDX
5QDY
5QDZ
5QE0
5QE1
5QE2
5QE3
5QE4
5QE5
5QE6
5QE7
5QE8
5QE9
5QEA
5QEB
5QEC
5QED
5QEE
5QEF
5QEG
5QEH
5QEI
5QEJ
5QEK
5QEL
5QEM
5QEN
5QEO
5QEP
5QEQ
5QER
5QES
5QET
5QEU
5QEV
5QEW
5QEX
5QEY
5QEZ
5QF0
5QF1
5QF2
5QF3
5QF4
5QF5
5QF6
5QF7
5QF8
5QF9
5QFA
5QFB
5QFC
5QFD
5QFE
5QFF
5QFG
5QFH
5QFI
5QFJ
5QFK
5QFL
5QFM
5QFN
5QFO
5QFP
5QFQ
5QFR
5QFS
5QFT
5QFU
5QFV
5QFW
5QFX
5QFY
5QFZ
5QG0
5QG1
5QG2
5QG3
5QG4
5QG5
5QG6
5QG7
5QG8
5QG9
5QGA
5QGB
5QGC
5QGD
5QGE
5QGF
5T19
6B8E
6B8T
6B8X
6B8Z
6B90
6B95
6BAI
6CWU
6CWV
6NTP
6OL4
6OLQ
6OLV
6OMY
6PFW
6PG0
6PGT
6PHA
6PHS
6PM8
Enriched GO Terms of Interacting Partners
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