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ASS1 and TERF2
Data Source:
BioGRID
(two hybrid)
ASS1
TERF2
Description
argininosuccinate synthase 1
telomeric repeat binding factor 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Lysosome
Endoplasmic Reticulum
Cytosol
Perikaryon
Extracellular Exosome
Cell Body Fiber
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Nuclear Body
Mre11 Complex
Shelterin Complex
Axon Cytoplasm
Molecular Function
RNA Binding
Argininosuccinate Synthase Activity
Protein Binding
ATP Binding
Toxic Substance Binding
Amino Acid Binding
Identical Protein Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Urea Cycle
Citrulline Metabolic Process
Argininosuccinate Metabolic Process
Kidney Development
Liver Development
Arginine Biosynthetic Process
Aspartate Metabolic Process
Acute-phase Response
Midgut Development
Aging
Response To Nutrient
Circadian Rhythm
Response To Zinc Ion
Response To Mycotoxin
Response To Estradiol
Response To Drug
Positive Regulation Of Nitric Oxide Biosynthetic Process
Response To Growth Hormone
Diaphragm Development
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Ammonium Ion
Cellular Response To CAMP
Cellular Response To Interferon-gamma
Cellular Response To Tumor Necrosis Factor
Cellular Response To Glucagon Stimulus
Cellular Response To Oleic Acid
Cellular Response To Amine Stimulus
Cellular Response To Laminar Fluid Shear Stress
Cellular Response To Dexamethasone Stimulus
Negative Regulation Of Leukocyte Cell-cell Adhesion
Telomere Maintenance
In Utero Embryonic Development
RNA-dependent DNA Biosynthetic Process
Cell Cycle
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Positive Regulation Of Nitric-oxide Synthase Activity
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Beta-galactosidase Activity
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Exonuclease Activity
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Pathways
Urea cycle
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Arginine
Aspartic acid
Aspartic acid
Citrulline
Citrulline
ATP
Diseases
Citrullinemia (CTLN)
GWAS
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Interacting Genes
15 interacting genes:
AKTIP
APP
ARAF
ASCC2
ELN
JAK2
LINC01554
MLH1
MT2A
PTPN1
SLC13A1
SUMO2
TERF1
TERF2
USP4
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
Entrez ID
445
7014
HPRD ID
04590
03610
Ensembl ID
ENSG00000130707
ENSG00000132604
Uniprot IDs
P00966
Q5T6L4
Q15554
PDB IDs
2NZ2
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
Enriched GO Terms of Interacting Partners
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