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MNAT1 and E2F1
Data Source:
HPRD
(in vitro)
MNAT1
E2F1
Description
MNAT1 component of CDK activating kinase
E2F transcription factor 1
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Protein N-terminus Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Adult Heart Development
Ventricular System Development
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Calcium Ion
Protein-containing Complex Assembly
Negative Regulation Of DNA Helicase Activity
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Viral Process
Forebrain Development
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease (
29631575
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Refractive error (
32231278
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Interacting Genes
48 interacting genes:
BEX3
BRCA1
CDK7
COPS6
DMAP1
E2F1
EEF1A1
ERCC2
ERCC3
ESR1
FOXP1
GOLGA2
GTF2E2
GTF2H1
GTF2H2
HPS6
LRIF1
MAGEC2
MAGEE2
MCM7
MDM4
MKRN3
MTA1
NKX3-1
POLR2A
POU2F1
POU2F2
POU5F1
RB1
RBM48
RNF32
RNF41
RNF7
SUPT5H
TET2
TP53
TRIM14
TRIM17
TRIM2
TRIM21
TRIM26
TRIM31
TRIM34
TRIM39
TRIM5
TRIM9
TRIML1
USP2
82 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
4331
1869
HPRD ID
04042
01806
Ensembl ID
ENSG00000020426
ENSG00000101412
Uniprot IDs
A0A024R669
A0A024R688
P51948
Q01094
Q9BSD8
PDB IDs
1G25
6NMI
6O9L
6O9M
6XBZ
6XD3
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
Enriched GO Terms of Interacting Partners
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