MN1 and NCOA3

Data Source:
BioGRID (pull down)

		MN1	NCOA3
Description		MN1 proto-oncogene, transcriptional regulator	nuclear receptor coactivator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Disordered Domain Specific Binding
	Biological Process	Intramembranous Ossification Regulation Of Transcription, DNA-templated Multicellular Organism Development Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition	Histone Acetylation Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division
Pathways			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Age-related cataracts ( 25352737) Blood pressure (smoking interaction) ( 25189868) FEV1 ( 30804560) Lung function (FEV1) ( 28166213 26635082) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 26635082) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mitral valve prolapse ( 26301497) Moderate or severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis ( 31749835) Peak expiratory flow ( 30804560) Platelet count ( 32888494 27863252) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 32888494 27863252) Pulse pressure ( 30224653) Red blood cell count ( 32888494) Refractive error ( 32231278) Resting heart rate ( 27798624) Urate levels in obese individuals ( 25811787)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		2 interacting genes: EP300 NCOA3	82 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		4330	8202
HPRD ID		08862	03570
Ensembl ID		ENSG00000169184	ENSG00000124151
Uniprot IDs		A0A024R1C3 Q10571	Q59EE8 Q9Y6Q9
PDB IDs			1KBH 3L3X 3L3Z 6ES7 6SQC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?