MMP17 and POLE

Data Source:
BioGRID (proximity labelling technology)

		MMP17	POLE
Description		matrix metallopeptidase 17	DNA polymerase epsilon, catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Extracellular Matrix Anchored Component Of Membrane	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Catalytic Activity	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Activation of Matrix Metalloproteinases	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Marimastat	Cladribine
Diseases
GWAS		Body mass index ( 26426971) Migraine ( 22683712) Psychosis proneness (perceptual aberration scale) ( 28525603)	Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		3 interacting genes: LRP1 MMP2 TNF	12 interacting genes: ABHD16A GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 STK19 TOPBP1 XRCC5
Entrez ID		4326	5426
HPRD ID		03793	07177
Ensembl ID		ENSG00000198598	ENSG00000177084
Uniprot IDs		Q9ULZ9	Q07864
PDB IDs			5VBN
Enriched GO Terms of Interacting Partners?
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