MMP1 and BCAN

Data Source:
HPRD (in vitro)

		MMP1	BCAN
Description		matrix metallopeptidase 1	brevican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Extracellular Region Golgi Lumen Extracellular Matrix Anchored Component Of Membrane Lysosomal Lumen Glutamatergic Synapse
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Proteolysis Viral Process Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Protein Metabolic Process Leukocyte Migration Cellular Response To UV-A	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Synapse Maturation
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling	Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Marimastat CGS-27023 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058)	Blood protein levels ( 30072576 29875488)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		4312	63827
HPRD ID		00384	02644
Ensembl ID		ENSG00000196611	ENSG00000132692
Uniprot IDs		B4DN15 P03956 Q53G95	Q96GW7
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?
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