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MME and SHC1
Data Source:
HPRD
(in vitro)
MME
SHC1
Description
membrane metalloendopeptidase
SHC adaptor protein 1
Image
GO Annotations
Cellular Component
Cytoplasm
Early Endosome
Trans-Golgi Network
Plasma Membrane
Integral Component Of Plasma Membrane
Brush Border
Focal Adhesion
Synaptic Vesicle
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Secretory Granule Membrane
Cytoplasmic Vesicle
Neuronal Cell Body
Neuron Projection Terminus
Membrane Raft
Synapse
Extracellular Exosome
Presynapse
Mitochondrial Matrix
Cytosol
Plasma Membrane
Shc-EGFR Complex
Molecular Function
Phosphatidylserine Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Protein Binding
Metallopeptidase Activity
Exopeptidase Activity
Zinc Ion Binding
Peptide Binding
Protein Homodimerization Activity
Oligopeptidase Activity
Cardiolipin Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Biological Process
Kidney Development
Placenta Development
Angiotensin Maturation
Proteolysis
Peptide Metabolic Process
Aging
Learning Or Memory
Protein Processing
Sensory Perception Of Pain
Lung Development
Neutrophil Degranulation
Creatinine Metabolic Process
Amyloid-beta Metabolic Process
Positive Regulation Of Neurogenesis
Neuropeptide Processing
Cellular Response To Cytokine Stimulus
Cellular Response To UV-A
Cellular Response To UV-B
Replicative Senescence
Amyloid-beta Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of Long-term Synaptic Potentiation
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Ras Protein Signal Transduction
Axon Guidance
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Reorganization
Interleukin-15-mediated Signaling Pathway
IRE1-mediated Unfolded Protein Response
Fc-epsilon Receptor Signaling Pathway
Interleukin-2-mediated Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of Growth
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Ras Protein Signal Transduction
Leukocyte Migration
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cell-cell Adhesion
Pathways
Metabolism of Angiotensinogen to Angiotensins
Neutrophil degranulation
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Candoxatril
Omapatrilat
N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
Phosphoramidon
N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala
Daglutril
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
Thiorphan
Sacubitril
Candoxatrilat
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Primary sclerosing cholangitis (
27992413
)
Systolic blood pressure (
27841878
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil counts (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Interacting Genes
18 interacting genes:
ADCYAP1
ADM
AGT
CSNK2A1
CSNK2B
EDN1
EDN2
EZR
GAST
LYN
NDRG1
NPPA
NPPC
PIK3CB
PIK3R1
PTEN
SHC1
VIP
143 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
Entrez ID
4311
6464
HPRD ID
00392
02780
Ensembl ID
ENSG00000196549
ENSG00000160691
Uniprot IDs
P08473
P29353
PDB IDs
1DL9
1DMT
1QVD
1R1H
1R1I
1R1J
1Y8J
2QPJ
2YB9
4CTH
5JMY
6GID
6SH1
6SH2
6SUK
6SVY
6THP
6XVP
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
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