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MME and ADM
Data Source:
HPRD
(in vitro)
MME
ADM
Description
membrane metalloendopeptidase
adrenomedullin
Image
GO Annotations
Cellular Component
Cytoplasm
Early Endosome
Trans-Golgi Network
Plasma Membrane
Integral Component Of Plasma Membrane
Brush Border
Focal Adhesion
Synaptic Vesicle
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Secretory Granule Membrane
Cytoplasmic Vesicle
Neuronal Cell Body
Neuron Projection Terminus
Membrane Raft
Synapse
Extracellular Exosome
Presynapse
Extracellular Region
Extracellular Space
Cytoplasm
Molecular Function
Phosphatidylserine Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Protein Binding
Metallopeptidase Activity
Exopeptidase Activity
Zinc Ion Binding
Peptide Binding
Protein Homodimerization Activity
Oligopeptidase Activity
Cardiolipin Binding
Signaling Receptor Binding
Hormone Activity
Adrenomedullin Receptor Binding
Biological Process
Kidney Development
Placenta Development
Angiotensin Maturation
Proteolysis
Peptide Metabolic Process
Aging
Learning Or Memory
Protein Processing
Sensory Perception Of Pain
Lung Development
Neutrophil Degranulation
Creatinine Metabolic Process
Amyloid-beta Metabolic Process
Positive Regulation Of Neurogenesis
Neuropeptide Processing
Cellular Response To Cytokine Stimulus
Cellular Response To UV-A
Cellular Response To UV-B
Replicative Senescence
Amyloid-beta Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of Long-term Synaptic Potentiation
Vasculogenesis
Response To Hypoxia
Neural Tube Closure
Regulation Of The Force Of Heart Contraction
G Protein-coupled Receptor Internalization
Regulation Of Systemic Arterial Blood Pressure
Inflammatory Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Heart Development
Female Pregnancy
Aging
Androgen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Cold
Response To Wounding
Positive Regulation Of Heart Rate
Animal Organ Regeneration
Neuron Projection Regeneration
Receptor Internalization
Response To Lipopolysaccharide
Response To Insulin
Regulation Of Urine Volume
Odontogenesis Of Dentin-containing Tooth
Response To Starvation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Vascular Permeability
Positive Regulation Of Angiogenesis
Negative Regulation Of Vasoconstriction
Hormone Secretion
Developmental Growth
Response To Glucocorticoid
Branching Involved In Labyrinthine Layer Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Amylin Receptor Signaling Pathway
Adrenomedullin Receptor Signaling Pathway
Positive Regulation Of Progesterone Biosynthetic Process
Positive Regulation Of Vasculogenesis
Pathways
Metabolism of Angiotensinogen to Angiotensins
Neutrophil degranulation
G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Candoxatril
Omapatrilat
N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
Phosphoramidon
N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala
Daglutril
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
Thiorphan
Sacubitril
Candoxatrilat
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Primary sclerosing cholangitis (
27992413
)
Systolic blood pressure (
27841878
)
Birth weight (
31043758
)
Blood pressure (
21909110
)
Blood protein levels in cardiovascular risk (
28369058
)
Circulating vasoactive peptide levels (
23381795
)
Diastolic blood pressure (
27841878
21909115
27618452
)
HDL cholesterol (
20686565
)
Neuroticism (
27089181
)
Pulse pressure (
27841878
)
Schizophrenia, bipolar disorder and depression (combined) (
20713499
)
Systolic blood pressure (
27841878
21909115
27618452
)
Interacting Genes
18 interacting genes:
ADCYAP1
ADM
AGT
CSNK2A1
CSNK2B
EDN1
EDN2
EZR
GAST
LYN
NDRG1
NPPA
NPPC
PIK3CB
PIK3R1
PTEN
SHC1
VIP
4 interacting genes:
CALCRL
CFH
EDN1
MME
Entrez ID
4311
133
HPRD ID
00392
00061
Ensembl ID
ENSG00000196549
ENSG00000148926
Uniprot IDs
P08473
P35318
PDB IDs
1DL9
1DMT
1QVD
1R1H
1R1I
1R1J
1Y8J
2QPJ
2YB9
4CTH
5JMY
6GID
6SH1
6SH2
6SUK
6SVY
6THP
6XVP
2FLY
2L7S
4RWF
5V6Y
6UUN
6UUS
6V2E
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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