ISY1 and KDM8

Data Source:
BioGRID (two hybrid)

		ISY1	KDM8
Description		ISY1 splicing factor homolog	lysine demethylase 8
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Post-spliceosomal Complex	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	RNA Binding Protein Binding	Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding 2-oxoglutarate-dependent Dioxygenase Activity Methylated Histone Binding Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific) L-arginine 3-hydroxylase Activity
	Biological Process	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair	G2/M Transition Of Mitotic Cell Cycle Proteolysis Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Histone H3-K36 Demethylation
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 31959851 31619474) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)
Interacting Genes		9 interacting genes: CCNC EXOC8 FAM90A1 KDM8 LMO1 LMO2 MLH1 WBP4 XAB2	6 interacting genes: DDIT4L IFT20 ISY1 MEOX2 NUBPL PCYT2
Entrez ID		57461	79831
HPRD ID		13834	07836
Ensembl ID		ENSG00000240682	ENSG00000155666
Uniprot IDs		Q9ULR0	A0A0S2Z5P8 A0A0S2Z5T1 Q8N371
PDB IDs		5YZG 6FF7 6ZYM 7A5P	3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N
Enriched GO Terms of Interacting Partners?
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