CCR3 and FGR

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CCR3	FGR
Description		C-C motif chemokine receptor 3	FGR proto-oncogene, Src family tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Aggresome Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Neutrophil Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Dasatinib Fostamatinib Zanubrutinib
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 23291587) Blood protein levels ( 28240269) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 22057235 20190752 25920553 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 29403010 27863252) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)	Body mass index ( 28892062) Systolic blood pressure ( 30224653)
Interacting Genes		19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK	30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		1232	2268
HPRD ID		03167	01288
Ensembl ID		ENSG00000183625	ENSG00000000938
Uniprot IDs		A1LPE5 P51677 Q8TDP4 Q8TDP5	P09769 P78453
PDB IDs
Enriched GO Terms of Interacting Partners?
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