ASAH1 and SMPD1

Data Source:
HPRD (in vitro)

		ASAH1	SMPD1
Description		N-acylsphingosine amidohydrolase 1	sphingomyelin phosphodiesterase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Early Endosome Endoplasmic Reticulum Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Space Lysosome Endosome Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity Ceramidase Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Fatty Acid Metabolic Process Glycosphingolipid Metabolic Process Keratinocyte Differentiation Neutrophil Degranulation Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor	Plasma Membrane Repair Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Wound Healing Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endocytosis Ceramide Biosynthetic Process Viral Entry Into Host Cell Response To Interleukin-1 Cellular Response To Calcium Ion
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Glycosphingolipid metabolism
Drugs			Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases		Farber lipogranulomatosis; Farber disease	Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Atrial fibrillation ( 28416818 30061737 29892015) Night sleep phenotypes ( 27126917) Obesity ( 21552555) Type 2 diabetes ( 32499647)	Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		427	6609
HPRD ID		01969	06353
Ensembl ID		ENSG00000104763	ENSG00000166311
Uniprot IDs		A8K0B6 Q13510 Q53H01	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		5U7Z 6MHM	5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?
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