SMPD1 and DUSP23

Data Source:
BioGRID (two hybrid)

		SMPD1	DUSP23
Description		sphingomyelin phosphodiesterase 1	dual specificity phosphatase 23
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GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Plasma Membrane Repair Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Wound Healing Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endocytosis Ceramide Biosynthetic Process Viral Entry Into Host Cell Response To Interleukin-1 Cellular Response To Calcium Ion	Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Glycosphingolipid metabolism
Drugs		Amlodipine Chlorpromazine Desipramine Medical Cannabis	4-Nitrophenyl Phosphate
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)	Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746
Entrez ID		6609	54935
HPRD ID		06353	07908
Ensembl ID		ENSG00000166311	ENSG00000158716
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	A0A140VJI5 Q9BVJ7
PDB IDs		5I81 5I85 5I8R 5JG8	2IMG 4ERC
Enriched GO Terms of Interacting Partners?
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