KITLG and PIK3CD

Data Source:
HPRD (in vivo)

		KITLG	PIK3CD
Description		KIT ligand	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	MAPK Cascade Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	Natural Killer Cell Differentiation Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation
Pathways			PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib
Diseases		Familial progressive hyperpigmentation
GWAS		Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240) Youthful appearance (self-reported) ( 32339537)	Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)
Interacting Genes		8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1	15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 PIK3R3 RALY TAGLN TNPO2
Entrez ID		4254	5293
HPRD ID		01698	04161
Ensembl ID		ENSG00000049130	ENSG00000171608
Uniprot IDs		A0A024RBC0 A0A024RBF5 P21583	A0A2K8FKV1 O00329
PDB IDs		1EXZ 1SCF 2E9W	5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU
Enriched GO Terms of Interacting Partners?
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