PIK3CD and MCRIP2

Data Source:
HPRD (two hybrid)

		PIK3CD	MCRIP2
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	MAPK regulated corepressor interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane	Nucleus Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity	Protein Binding
	Biological Process	Natural Killer Cell Differentiation Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)
Interacting Genes		15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 PIK3R3 RALY TAGLN TNPO2	2 interacting genes: EEF1G PIK3CD
Entrez ID		5293	84331
HPRD ID		04161	17503
Ensembl ID		ENSG00000171608	ENSG00000172366
Uniprot IDs		A0A2K8FKV1 O00329	Q9BUT9
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU
Enriched GO Terms of Interacting Partners?
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