KITLG and FLT3LG

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		KITLG	FLT3LG
Description		KIT ligand	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	MAPK Cascade Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis
Pathways			PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs
Diseases		Familial progressive hyperpigmentation
GWAS		Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240) Youthful appearance (self-reported) ( 32339537)	Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1	4 interacting genes: FLT3 KITLG KRTAP5-9 PFN2
Entrez ID		4254	2323
HPRD ID		01698	02477
Ensembl ID		ENSG00000049130	ENSG00000090554
Uniprot IDs		A0A024RBC0 A0A024RBF5 P21583	B7ZLY4 M0QYM9 P49771
PDB IDs		1EXZ 1SCF 2E9W	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?
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