MAP3K3 and MAP2K3

Data Source:
BioGRID (enzymatic study)

		MAP3K3	MAP2K3
Description		mitogen-activated protein kinase kinase kinase 3	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol Membrane
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence	Activation Of MAPK Activity Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction
Pathways		Interleukin-1 signaling	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)	Body mass index ( 26426971 28892062)
Interacting Genes		42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		4215	5606
HPRD ID		03965	03816
Ensembl ID		ENSG00000198909	ENSG00000034152
Uniprot IDs		J3KRN4 Q96HN9 Q99759	P46734 Q6FI23
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6
Enriched GO Terms of Interacting Partners?
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