MCF2 and SHANK2

Data Source:
BioGRID (biochemical)

		MCF2	SHANK2
Description		MCF.2 cell line derived transforming sequence	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		8 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG STUB1 TNK2	19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		4168	22941
HPRD ID		02406	04479
Ensembl ID		ENSG00000101977	ENSG00000162105
Uniprot IDs		B2R9S6 P10911	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?
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