MCC and BAAT

Data Source:
BioGRID (two hybrid)

		MCC	BAAT
Description		MCC regulator of WNT signaling pathway	bile acid-CoA:amino acid N-acyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Palmitoyl-CoA Hydrolase Activity N-acyltransferase Activity Transferase Activity, Transferring Acyl Groups Choloyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Glycine N-choloyltransferase Activity Carboxylic Ester Hydrolase Activity Medium-chain Acyl-CoA Hydrolase Activity Long-chain Acyl-CoA Hydrolase Activity Very Long Chain Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Liver Development Bile Acid Conjugation Glycine Metabolic Process Protein Targeting To Peroxisome Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Taurine Metabolic Process Animal Organ Regeneration
Pathways			Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Peroxisomal protein import Peroxisomal protein import
Drugs			Glycine
Diseases			Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549)
Interacting Genes		79 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CSNK1E CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 IMP3 KAT5 KIF3C KIFC3 LRRC45 MAGEE1 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	24 interacting genes: APC AURKA BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 GOLGA8DP GOLGA8EP GOLGA8F MCC MLH1 MLH3 MUTYH ODC1 PDGFRL PEX5 PTPRJ RAD54B RB1 SLC7A11 SMAD4 SRC
Entrez ID		4163	570
HPRD ID		01157	08376
Ensembl ID		ENSG00000171444	ENSG00000136881
Uniprot IDs		P23508	Q14032
PDB IDs		6MTU 6MTV
Enriched GO Terms of Interacting Partners?
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