MBD1 and ECT2

Data Source:
BioGRID (two hybrid)

		MBD1	ECT2
Description		methyl-CpG binding domain protein 1	epithelial cell transforming 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		SUMOylation of transcription cofactors	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		25 interacting genes: APP ATF7IP ATF7IP2 ATXN1L CBX4 CBX5 CHAF1A ECT2 HDAC3 HIPK3 HTT OASL PIAS1 PIAS2 RNF2 SETDB1 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SP1 SUV39H1 TENM1 ZNF512B	38 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2
Entrez ID		4152	1894
HPRD ID		01133	11860
Ensembl ID		ENSG00000141644	ENSG00000114346
Uniprot IDs		A8K654 B4DI41 B4DUR3 Q9UIS9	Q9H8V3
PDB IDs		1D9N 1IG4 4D4W 5W9Q 6D1T	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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