MAT2A and MAT1A

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical)

		MAT2A	MAT1A
Description		methionine adenosyltransferase 2A	methionine adenosyltransferase 1A
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GO Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Cytosol
	Molecular Function	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Protein Hexamerization Protein Heterooligomerization Cellular Response To Leukemia Inhibitory Factor	Sulfur Amino Acid Metabolic Process Selenium Compound Metabolic Process S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methionine Catabolic Process Methylation Protein Homotetramerization
Pathways		Methylation	Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Drugs		Ademetionine	Ademetionine 3-Oxiran-2ylalanine L-2-amino-4-methoxy-cis-but-3-enoic acid
Diseases			Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Coronary artery disease ( 29212778 30104761) Dysmenorrheic pain ( 27454463) Urinary albumin excretion ( 30220432)	Diabetic kidney disease ( 26305897)
Interacting Genes		7 interacting genes: CUL3 HGS MAT1A MAT2B PRC1 TMEM213 UBE2I	1 interacting genes: MAT2A
Entrez ID		4144	4143
HPRD ID		03275	02013
Ensembl ID		ENSG00000168906	ENSG00000151224
Uniprot IDs		A0A140VJP5 P31153	Q00266
PDB IDs		2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V	2OBV 6SW5 6SW6
Enriched GO Terms of Interacting Partners?
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