MAT1A and MAT2A

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical)

		MAT1A	MAT2A
Description		methionine adenosyltransferase 1A	methionine adenosyltransferase 2A
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GO Annotations	Cellular Component	Cytosol	Cytosol Methionine Adenosyltransferase Complex
	Molecular Function	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Selenium Compound Metabolic Process S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methionine Catabolic Process Methylation Protein Homotetramerization	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Protein Hexamerization Protein Heterooligomerization Cellular Response To Leukemia Inhibitory Factor
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)	Methylation
Drugs		Ademetionine 3-Oxiran-2ylalanine L-2-amino-4-methoxy-cis-but-3-enoic acid	Ademetionine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Diabetic kidney disease ( 26305897)	Coronary artery disease ( 29212778 30104761) Dysmenorrheic pain ( 27454463) Urinary albumin excretion ( 30220432)
Interacting Genes		1 interacting genes: MAT2A	7 interacting genes: CUL3 HGS MAT1A MAT2B PRC1 TMEM213 UBE2I
Entrez ID		4143	4144
HPRD ID		02013	03275
Ensembl ID		ENSG00000151224	ENSG00000168906
Uniprot IDs		Q00266	A0A140VJP5 P31153
PDB IDs		2OBV 6SW5 6SW6	2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V
Enriched GO Terms of Interacting Partners?
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