SIRT1 and FOXO3

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, two hybrid, in vitro)

		SIRT1	FOXO3
Description		sirtuin 1	forkhead box O3
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Mitochondrion Cytosol PML Body RDNA Heterochromatin ESC/E(Z) Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity Enzyme Binding Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Nuclear Hormone Receptor Binding Histone Binding Identical Protein Binding HLH Domain Binding BHLH Transcription Factor Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) Mitogen-activated Protein Kinase Binding NAD+ Binding Protein-propionyllysine Depropionylase Activity Keratin Filament Binding Promoter-specific Chromatin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Single Strand Break Repair Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Synthesis Involved In DNA Repair Angiogenesis Ovulation From Ovarian Follicle Cellular Glucose Homeostasis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Adaptive Immune Response Chromatin Organization DNA Methylation-dependent Heterochromatin Assembly Protein ADP-ribosylation Protein Deacetylation Triglyceride Mobilization Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Regulation Of Mitotic Cell Cycle Muscle Organ Development Cell Aging Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Positive Regulation Of Macroautophagy Protein Ubiquitination Histone Deacetylation Peptidyl-lysine Acetylation Macrophage Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Prostaglandin Biosynthetic Process Heterochromatin Assembly Protein Destabilization Negative Regulation Of TOR Signaling Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Insulin Circadian Regulation Of Gene Expression Leptin-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Peptidyl-lysine Deacetylation Cellular Triglyceride Homeostasis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Response To Hydrogen Peroxide Behavioral Response To Starvation Cholesterol Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Leptin Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway White Fat Cell Differentiation Negative Regulation Of Helicase Activity Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Protein Kinase B Signaling Fatty Acid Homeostasis Negative Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Cellular Response To Hydrogen Peroxide Heterochromatin Maintenance Regulation Of Bile Acid Biosynthetic Process UV-damage Excision Repair Histone H3 Deacetylation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Histone H3-K14 Acetylation Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Protein Depropionylation Regulation Of Cellular Response To Heat Negative Regulation Of Histone H3-K9 Trimethylation Negative Regulation Of Neuron Death Negative Regulation Of Protein Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Adipose Tissue Development Histone H3-K9 Deacetylation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Cellular Response To Testosterone Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Apoptotic Process Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Fatty Acid Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Regulation of HSF1-mediated heat shock response Circadian Clock SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation	Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Resveratrol Selisistat Cambinol
Diseases
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Diverticular disease ( 30177863) Molybdenum levels ( 26025379) Pulse pressure ( 30224653)	Adult body size ( 32376654) Anxiety/tension (special factor of neuroticism) ( 30867560) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 32888494 27863252) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		63 interacting genes: AFP AKT1 AR ARNTL BCL11A BHLHE41 BRIP1 CDK6 CENATAC CHFR CLOCK CSNK2B CTTN E2F1 EP300 ESRRA EZH2 FOS FOXM1 FOXO1 FOXO3 GAPDH H1-5 H3C1 HES1 HEY2 HIC1 HIPK2 HNF4A HOXB9 MAPK8 MAPT MPHOSPH8 MYCN NBN NDN NMNAT1 NR1H2 NR1H3 NR1H4 PARP1 PML PPARA PPARG PPARGC1A PRMT1 PSME3 RARA RELA RICTOR RRP8 SATB1 SETD7 SMAD7 SNW1 STK11 STK4 SUMO2 TP53 TP73 TRIM28 UBE2I VDR	27 interacting genes: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBIN ESR1 FOXG1 IKBKB MAPK1 MAPK6 MDM2 NR1H2 NR1H3 PTPA SGK1 SIRT1 SMAD2 SMAD3 SMAD4 TERT TP53 VDR YWHAG YWHAZ
Entrez ID		23411	2309
HPRD ID		08381	04061
Ensembl ID		ENSG00000096717	ENSG00000118689
Uniprot IDs		A0A024QZQ1 A8K128 B0QZ35 E9PC49 Q96EB6	O43524
PDB IDs		4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR	2K86 2LQH 2LQI 2UZK 6MNL
Enriched GO Terms of Interacting Partners?
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