MIR19B1 and CPSF2

Data Source:
BioGRID (unspecified method)

		MIR19B1	CPSF2
Description		microRNA 19b-1	cleavage and polyadenylation specific factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Perinuclear Region Of Cytoplasm Blood Microparticle Extracellular Vesicle	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane
	Molecular Function	MRNA Binding Involved In Posttranscriptional Gene Silencing	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-6 Production Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Negative Regulation Of Coagulation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Bacterial Lipopeptide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cholesterol Efflux Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Apoptotic Process Involved In Development Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Export From Nucleus MRNA 3'-end Processing Pre-mRNA Cleavage Required For Polyadenylation
Pathways			Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS			3-month functional outcome in lacunar ischaemic stroke (modified Rankin score) ( 30796134) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) Dialysis-related mortality ( 21546767) Height ( 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Monobrow ( 27182965) Myopia ( 27182965) Obesity-related traits ( 23251661) Refractive error ( 32231278)
Interacting Genes		103 interacting genes: AIMP1 AIMP2 APOBEC3B AQR C1QBP CELF1 CELF2 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBBP6 RBFOX2 RBM12B RBM14 RBM4 RBMS2 RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 WDR33 WWP1 WWP2 YBX1 YBX2 YBX3 ZNF346 ZNF385A	10 interacting genes: MIR19A MIR19B1 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A3 MIRLET7F2 POLR2A SUMO2 WWOX
Entrez ID		406980	53981
HPRD ID			05824
Ensembl ID		ENSG00000284375	ENSG00000165934
Uniprot IDs			A0A024R6H0 Q9P2I0
PDB IDs			6URG 6V4X
Enriched GO Terms of Interacting Partners?
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