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ADARB1 and EIF2AK2
Data Source:
BioGRID
(two hybrid)
ADARB1
EIF2AK2
Description
adenosine deaminase RNA specific B1
eukaryotic translation initiation factor 2 alpha kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Synapse
Nucleus
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
Double-stranded RNA Binding
Double-stranded RNA Adenosine Deaminase Activity
MRNA Binding
Protein Binding
TRNA-specific Adenosine Deaminase Activity
Metal Ion Binding
RNA Binding
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Regulator Activity
Identical Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Adenosine To Inosine Editing
RNA Processing
MRNA Processing
Neuromuscular Synaptic Transmission
Negative Regulation Of Cell Population Proliferation
Base Conversion Or Substitution Editing
Facial Nerve Morphogenesis
Hypoglossal Nerve Morphogenesis
Spinal Cord Ventral Commissure Morphogenesis
Negative Regulation Of Cell Migration
Multicellular Organism Growth
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Viral Genome Replication
Innate Immune Response
Neuromuscular Process Controlling Posture
Defense Response To Virus
Regulation Of Cell Cycle
Innervation
Muscle Tissue Morphogenesis
Motor Behavior
Motor Neuron Apoptotic Process
Activation Of MAPKK Activity
Positive Regulation Of Cytokine Production
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Response To Virus
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Negative Regulation Of Translation
Peptidyl-tyrosine Phosphorylation
Mitigation Of Host Immune Response By Virus
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Cellular Response To Amino Acid Starvation
Response To Interferon-alpha
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
C6 deamination of adenosine
Formation of editosomes by ADAR proteins
ISG15 antiviral mechanism
Inhibition of PKR
Drugs
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Body mass index (
28892062
25673413
)
HDL cholesterol levels (
32203549
)
Logical memory (immediate recall) in mild cognitive impairment (
29274321
)
Pulmonary function (
17903307
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30130595
)
Glucose homeostasis traits (
25524916
)
Platelet count (
32888494
)
Interacting Genes
54 interacting genes:
APP
EHHADH
EIF2AK2
MIR1-1
MIR1-2
MIR106A
MIR138-1
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15B
MIR16-2
MIR199A2
MIR19B2
MIR200A
MIR200B
MIR206
MIR221
MIR222
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR363
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7F1
MIRLET7F2
MIRLET7G
NKRF
PIN1
PNPT1
PRKRA
STAU1
STOX1
STRBP
TARBP2
TCEANC
UBE2I
ZMAT4
ZNF346
124 interacting genes:
ADARB1
CASP3
CASP7
CASP8
CDC42
CHUK
DHX58
DHX9
DICER1
DNAJC3
EDC4
EIF2A
EIF2S1
EIF6
ELF2
FTSJ3
H2AC20
H2AC4
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
MAP3K5
MAP3K7
METAP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MOV10
NFKBIA
NPM1
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PTGES3
RAC1
STAT1
STAT3
STRBP
SUMO1
TAB2
TARBP2
THAP12
TIRAP
TOLLIP
TP53
TYK2
UBE2I
ZNF346
Entrez ID
104
5610
HPRD ID
06777
01468
Ensembl ID
ENSG00000197381
ENSG00000055332
Uniprot IDs
P78563
P19525
Q8IW76
PDB IDs
1ZY7
5ED1
5ED2
5HP2
5HP3
6D06
6VFF
1QU6
2A19
2A1A
3UIU
6D3K
6D3L
Enriched GO Terms of Interacting Partners
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