LYL1 and TCF3

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		LYL1	TCF3
Description		LYL1 basic helix-loop-helix family member	transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding
	Biological Process	Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Definitive Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Nervous System Development B Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		NGF-stimulated transcription	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Household income ( 31844048) Household income (MTAG) ( 31844048) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)	Hodgkin's lymphoma ( 29196614 24920014) Objective response to lithium treatment ( 26503763)
Interacting Genes		8 interacting genes: DRG1 LMO1 LMO2 NFKB1 NFKBIA RHOU TCF3 TCF4	67 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 TWIST2 UBE2I USF1
Entrez ID		4066	6929
HPRD ID		01046	00918
Ensembl ID		ENSG00000104903	ENSG00000071564
Uniprot IDs		P12980	A0A0A0MRB7 P15923 X6REB3
PDB IDs			1HLH 2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?
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