LTC4S and GPR42

Data Source:
BioGRID (two hybrid)

		LTC4S	GPR42
Description		leukotriene C4 synthase	G protein-coupled receptor 42
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle	Integral Component Of Plasma Membrane
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Cellular Oxidant Detoxification Lipoxin Biosynthetic Process	G Protein-coupled Receptor Signaling Pathway
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Drugs		Glutathione Azelastine
Diseases
GWAS
Interacting Genes		12 interacting genes: ALOX5 ALOX5AP CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B	104 interacting genes: ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERMP1 FAM3C FXYD3 FXYD6 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD5 MFSD6 MGAM MS4A1 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM262 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		4056	2866
HPRD ID		02004	16033
Ensembl ID		ENSG00000213316	ENSG00000126251
Uniprot IDs		Q16873	A0A0K0PUY3 O15529
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D
Enriched GO Terms of Interacting Partners?
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