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LTC4S and ALOX5
Data Source:
BioGRID
(fluorescent resonance energy transfer)
LTC4S
ALOX5
Description
leukotriene C4 synthase
arachidonate 5-lipoxygenase
Image
GO Annotations
Cellular Component
Nuclear Envelope
Nuclear Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Extracellular Region
Extracellular Space
Nuclear Envelope
Nuclear Envelope Lumen
Nucleoplasm
Cytosol
Nuclear Matrix
Nuclear Membrane
Secretory Granule Lumen
Perinuclear Region Of Cytoplasm
Ficolin-1-rich Granule Lumen
Molecular Function
Glutathione Transferase Activity
Leukotriene-C4 Synthase Activity
Glutathione Peroxidase Activity
Protein Binding
Enzyme Activator Activity
Lipid Binding
Identical Protein Binding
Arachidonate 5-lipoxygenase Activity
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Hydrolase Activity
Biological Process
Leukotriene Metabolic Process
Leukotriene Biosynthetic Process
Lipoxygenase Pathway
Long-chain Fatty Acid Biosynthetic Process
Regulation Of Catalytic Activity
Cellular Oxidant Detoxification
Lipoxin Biosynthetic Process
Negative Regulation Of Endothelial Cell Proliferation
Leukocyte Chemotaxis Involved In Inflammatory Response
Leukocyte Migration Involved In Inflammatory Response
Leukotriene Production Involved In Inflammatory Response
Leukotriene Metabolic Process
Humoral Immune Response
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Arachidonic Acid Metabolic Process
Leukotriene Biosynthetic Process
Lipoxygenase Pathway
Positive Regulation Of Bone Mineralization
Lipid Oxidation
Interleukin-18-mediated Signaling Pathway
Dendritic Cell Migration
Glucose Homeostasis
Long-chain Fatty Acid Biosynthetic Process
Neutrophil Degranulation
Linoleic Acid Metabolic Process
Regulation Of Fat Cell Differentiation
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Regulation Of Insulin Secretion
Hepoxilin Biosynthetic Process
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Regulation Of Inflammatory Response To Wounding
Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Cellular Response To Oxidative Stress
Leukotriene A4 Biosynthetic Process
Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Lipoxin Biosynthetic Process
Pathways
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Interleukin-18 signaling
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs
Glutathione
Azelastine
Vitamin E
Masoprocol
Aminosalicylic acid
Mesalazine
Montelukast
Diethylcarbamazine
Zileuton
Sulfasalazine
Meclofenamic acid
Balsalazide
Minocycline
Hyperforin
Resveratrol
Licofelone
MLN-977
Morniflumate
Diacerein
Fostamatinib
Rhein
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Diseases
GWAS
Cholesterol, total (
24097068
)
HDL cholesterol (
24097068
)
HDL cholesterol levels (
28334899
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
20139978
)
Mean corpuscular volume (
20139978
)
Total cholesterol levels (
28334899
)
Interacting Genes
12 interacting genes:
ALOX5
ALOX5AP
CD79A
CREB3L1
EBP
FFAR3
FXYD3
GPR152
GPR42
MGST1
SLC7A14
TMEM52B
27 interacting genes:
ACTB
ALOX5AP
ALPL
APP
C10orf67
CCDC174
CEP57L1
CEP63
COTL1
DICER1
GATC
GRB2
HHIPL2
HSD17B1
LCN1
LTC4S
MAD1L1
MAPKAPK2
MEOX1
MEOX2
MTDH
NUTM1
OOEP
REL
SYCE1
TBC1D7
TGFBRAP1
Entrez ID
4056
240
HPRD ID
02004
01065
Ensembl ID
ENSG00000213316
ENSG00000012779
Uniprot IDs
Q16873
P09917
PDB IDs
2PNO
2UUH
2UUI
3B29
3HKK
3LEO
3PCV
4BPM
4J7T
4J7Y
4JC7
4JCZ
4JRZ
4WAB
5HV9
6R7D
2ABV
3O8Y
3V92
3V98
3V99
6N2W
6NCF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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