ALOX5 and TBC1D7

Data Source:
BioGRID (two hybrid)

		ALOX5	TBC1D7
Description		arachidonate 5-lipoxygenase	TBC1 domain family member 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen	Cytosol Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity	GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Humoral Immune Response Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Interleukin-18-mediated Signaling Pathway Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Neutrophil Degranulation Linoleic Acid Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Hepoxilin Biosynthetic Process Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process	Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives	TBC/RABGAPs
Drugs		Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)	Migraine ( 23793025) Migraine without aura ( 23793025)
Interacting Genes		27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1	30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ
Entrez ID		240	51256
HPRD ID		01065	18165
Ensembl ID		ENSG00000012779	ENSG00000145979
Uniprot IDs		P09917	A0A024QZX0 A0A024R011 Q5JPB9 Q9P0N9 U3KPY5
PDB IDs		2ABV 3O8Y 3V92 3V98 3V99 6N2W 6NCF	3QWL 4Z6Y 5EJC 5ULO
Enriched GO Terms of Interacting Partners?
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