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PLPP6 and PRLR
Data Source:
BioGRID
(two hybrid)
PLPP6
PRLR
Description
phospholipid phosphatase 6
prolactin receptor
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Integral Component Of Membrane
Extracellular Region
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Endosome Lumen
Receptor Complex
Molecular Function
Protein Binding
Hydrolase Activity
Sphingosine-1-phosphate Phosphatase Activity
Lipid Phosphatase Activity
Cytokine Receptor Activity
Leukemia Inhibitory Factor Receptor Activity
Oncostatin-M Receptor Activity
Prolactin Receptor Activity
Ciliary Neurotrophic Factor Receptor Binding
Protein Binding
Peptide Hormone Binding
Cytokine Binding
Metal Ion Binding
Biological Process
Cholesterol Biosynthetic Process
Phospholipid Dephosphorylation
Steroid Biosynthetic Process
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
Embryo Implantation
Lactation
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Prolactin Signaling Pathway
Oncostatin-M-mediated Signaling Pathway
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Leukemia Inhibitory Factor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Cholesterol biosynthesis
Prolactin receptor signaling
Prolactin receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Diseases
GWAS
Advanced age-related macular degeneration (
26691988
)
Chronotype (
30696823
)
Metabolite levels (
23823483
)
Paneth cell defects in Crohn's disease (
28352666
)
Psychotic experience (
31553412
)
Response to lurasidone in schizophrenia (
29730043
)
Interacting Genes
57 interacting genes:
AMIGO1
AQP6
AQP8
BTN2A1
BTNL9
C16orf92
CD79A
CIAO2A
CLDN15
CLDN9
CLEC4M
CLN5
COMT
CREB3L1
EBP
FAM174A
FAM209A
FAM210B
FKBP7
FNDC9
FXYD3
GJB5
GKN1
GORAB
GPX8
HSH2D
IL10RA
IL13RA2
KASH5
LAYN
LDLRAD1
MMGT1
MS4A3
MUC1
NCR3LG1
PDGFRA
PDZK1IP1
PHACTR3
PRLR
PVR
RETREG3
RNF170
RNF5
SEC11C
SHISAL1
SIGLEC12
SLC7A14
SMAGP
SOCS4
SSMEM1
STX1A
SYNE4
SYNPR
TMEM106C
TMIE
TNFRSF10D
VSIR
20 interacting genes:
CISH
CREBBP
CSH1
FBXW11
GH1
INSIG2
JAK2
NEK3
PLPP6
PPIA
PRL
PTPN11
SOCS2
SOCS3
TEC
VAV1
VAV2
YWHAG
YWHAZ
ZAP70
Entrez ID
403313
5618
HPRD ID
17397
01457
Ensembl ID
ENSG00000205808
ENSG00000113494
Uniprot IDs
Q8IY26
P16471
PDB IDs
1BP3
2LFG
2N7I
3D48
3MZG
3N06
3N0P
3NCB
3NCC
3NCE
3NCF
4I18
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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