LNPEP and HSD17B11

Data Source:
BioGRID (two hybrid)

		LNPEP	HSD17B11
Description		leucyl and cystinyl aminopeptidase	hydroxysteroid 17-beta dehydrogenase 11
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Early Endosome Lumen	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Aminopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding Peptide Binding Metalloaminopeptidase Activity	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Signal Transduction Cell-cell Signaling Female Pregnancy Regulation Of Blood Pressure Peptide Catabolic Process Negative Regulation Of Cold-induced Thermogenesis	Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways		Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation	Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)	Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		33 interacting genes: AGT AQP6 ASGR2 CGRRF1 CTAG1A CTAG1B FAM210B FATE1 FCER1G FHOD1 GGT7 GPR42 GPX8 HSD17B11 LCN2 LHFPL5 MMGT1 REEP4 REL SLC2A4 SLC35E3 SLC39A9 SMAD9 SSMEM1 STOM TAS2R19 TCF4 TLCD4 TMEM35A TNKS TNKS2 UBQLN1 UNC93A	59 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LNPEP LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SEC22B SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX5 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VAPA VEZT YIF1A YIPF6
Entrez ID		4012	51170
HPRD ID		01041	10881
Ensembl ID		ENSG00000113441	ENSG00000198189
Uniprot IDs		Q9UIQ6	Q8NBQ5
PDB IDs		4P8Q 4PJ6 4Z7I 5C97 5JHQ 5MJ6	1YB1
Enriched GO Terms of Interacting Partners?
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