LMAN1 and MCFD2

Data Source:
HPRD (in vivo, in vitro)

		LMAN1	MCFD2
Description		lectin, mannose binding 1	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Sarcomere COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Mannose Binding Metal Ion Binding Unfolded Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Blood Coagulation Positive Regulation Of Organelle Organization Protein N-linked Glycosylation Via Asparagine Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport COPII Vesicle Coating Negative Regulation Of Protein Targeting To Mitochondrion	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Protein N-linked Glycosylation Via Asparagine COPII Vesicle Coating
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Combined deficiency of factors V and VIII (F5F8D)	Combined deficiency of factors V and VIII (F5F8D)
GWAS		Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Morning vs. evening chronotype ( 27494321)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		4 interacting genes: APP BCAP31 F8 MCFD2	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		3998	90411
HPRD ID		03338	09693
Ensembl ID		ENSG00000074695	ENSG00000180398
Uniprot IDs		A0A024R2A7 P49257	B4DF17 Q8NI22
PDB IDs		3A4U 3LCP 3WHT 3WHU 3WNX 4GKX 4GKY 4YGB 4YGC 4YGD 4YGE	2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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