MCFD2 and SYS1

Data Source:
BioGRID (two hybrid)

		MCFD2	SYS1
Description		multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	SYS1 golgi trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Trans-Golgi Network Cytosol Integral Component Of Golgi Membrane Trans-Golgi Network Membrane
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Protein N-linked Glycosylation Via Asparagine COPII Vesicle Coating	Golgi To Endosome Transport Protein Localization To Golgi Apparatus Golgi To Plasma Membrane Protein Transport
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification	Retrograde transport at the Trans-Golgi-Network
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Combined deficiency of factors V and VIII (F5F8D)
GWAS		Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)	Free cholesterol levels in large HDL ( 29084231) Large HDL particle concentration ( 29084231) Malaria ( 31844061) Mean diameter of HDL particles ( 29084231) Phospholipid levels in large HDL ( 29084231)
Interacting Genes		11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1	20 interacting genes: BTNL9 EBP ELOVL5 ERGIC3 FCER1G GLP1R HSD17B11 IL3RA KIR3DL3 MCFD2 MGST3 MRPS18B PSCA PVR SDCBP SLC30A8 SLC35C2 TM4SF19 TMEM248 TNFSF14
Entrez ID		90411	90196
HPRD ID		09693
Ensembl ID		ENSG00000180398	ENSG00000204070
Uniprot IDs		B4DF17 Q8NI22	Q8N2H4
PDB IDs		2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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