JTB and LIG3

Data Source:
HPRD (in vivo)

		JTB	LIG3
Description		jumping translocation breakpoint	DNA ligase 3
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Spindle Integral Component Of Plasma Membrane Membrane Midbody	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Protein Kinase Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Positive Regulation Of Protein Kinase Activity	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways			Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			Bleomycin
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)
Interacting Genes		4 interacting genes: APP ELOC LIG3 ZXDC	8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		10899	3980
HPRD ID		05240	02966
Ensembl ID		ENSG00000143543	ENSG00000005156
Uniprot IDs		O76095	P49916
PDB IDs		2KJX	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?
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