CNTFR and CRLF1

Data Source:
HPRD (in vitro, in vivo)

		CNTFR	CRLF1
Description		ciliary neurotrophic factor receptor	cytokine receptor like factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Interleukin-27-mediated Signaling Pathway Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling
Drugs
Diseases			Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576 29875488) Physiological traits ( 31902109)	Blood protein levels ( 30072576) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)
Interacting Genes		9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1	2 interacting genes: CLCF1 CNTFR
Entrez ID		1271	9244
HPRD ID		00348	09177
Ensembl ID		ENSG00000122756	ENSG00000006016
Uniprot IDs		P26992	O75462
PDB IDs		1UC6
Enriched GO Terms of Interacting Partners?
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