LAMC1 and WASHC3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMC1	WASHC3
Description		laminin subunit gamma 1	WASH complex subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Early Endosome WASH Complex
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity	Protein Binding
	Biological Process	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly	Exocytosis Biological_process Protein Transport Actin Filament Polymerization
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Lanoteplase
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)
Interacting Genes		14 interacting genes: ANTXR2 APP ATF7IP CENPU LAMA5 NID1 NID2 PSMC5 SNAPIN SNX2 SRPK1 TANK UBC WASHC3	56 interacting genes: ABI2 BFSP2 BLOC1S2 BLOC1S6 C20orf202 CCDC197 CCHCR1 CENPK CEP55 CKAP4 COG6 DTNBP1 GDF9 GNG13 GOLGA2 HAUS1 HSBP1 HSPB1 IFT20 IKBIP INSYN1 KDM1A KNSTRN KRT27 KRT6A KRT71 KRT75 LAMC1 LHX4 LMNB2 LUC7L2 MCRS1 MOB1A MOB1B MYOZ1 NDC80 NUP62 OPTN PAX6 PBXIP1 PCM1 PHOSPHO2 PTN RABEP1 SCARA5 SDCBP SNAP25 SNAPIN SRGAP2B SYCE1 TEX35 TFIP11 TXLNA TXLNB VPS52 WASHC1
Entrez ID		3915	51019
HPRD ID		01030	13031
Ensembl ID		ENSG00000135862	ENSG00000120860
Uniprot IDs		P11047 Q6NVY8	F5GWI9 F5GZ97 Q9Y3C0
PDB IDs		5XAU
Enriched GO Terms of Interacting Partners?
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