LAMC1 and LAMA5

Data Source:
BioGRID (biochemical, imaging technique)
HPRD (in vitro)

		LAMC1	LAMA5
Description		laminin subunit gamma 1	laminin subunit alpha 5
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity	Integrin Binding Extracellular Matrix Structural Constituent
	Biological Process	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Integrin-mediated Signaling Pathway Axon Guidance Muscle Organ Development Animal Organ Morphogenesis Tissue Development Morphogenesis Of Embryonic Epithelium Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling
Drugs		Lanoteplase	Lanoteplase
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)	Blood protein levels ( 29875488) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		14 interacting genes: ANTXR2 APP ATF7IP CENPU LAMA5 NID1 NID2 PSMC5 SNAPIN SNX2 SRPK1 TANK UBC WASHC3	15 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4
Entrez ID		3915	3911
HPRD ID		01030	03020
Ensembl ID		ENSG00000135862	ENSG00000130702
Uniprot IDs		P11047 Q6NVY8	O15230
PDB IDs		5XAU	5XAU
Enriched GO Terms of Interacting Partners?
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