LAMA5 and BTBD10

Data Source:
HPRD (two hybrid)

		LAMA5	BTBD10
Description		laminin subunit alpha 5	BTB domain containing 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Fibrillar Center Nucleoplasm Cytoplasm
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent	Protein Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Integrin-mediated Signaling Pathway Axon Guidance Muscle Organ Development Animal Organ Morphogenesis Tissue Development Morphogenesis Of Embryonic Epithelium Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Cell-cell Adhesion	Positive Regulation Of Phosphorylation Type B Pancreatic Cell Proliferation Negative Regulation Of Neuron Death
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling
Drugs		Lanoteplase
Diseases
GWAS		Blood protein levels ( 29875488) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)	Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		15 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4	8 interacting genes: ACIN1 CDC37 CUL3 DLG5 LAMA5 MAPK3 PPP1CA PPP1CC
Entrez ID		3911	84280
HPRD ID		03020	17045
Ensembl ID		ENSG00000130702	ENSG00000148925
Uniprot IDs		O15230	B7Z503 D3DQW7 Q9BSF8
PDB IDs		5XAU
Enriched GO Terms of Interacting Partners?
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