KTN1 and KIF5B

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		KTN1	KIF5B
Description		kinectin 1	kinesin family member 5B
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytosol Kinesin Complex Microtubule Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Axonal Growth Cone Phagocytic Vesicle Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	RNA Binding Protein Binding Kinesin Binding Cadherin Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding JUN Kinase Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Identical Protein Binding Cadherin Binding Microtubule Lateral Binding
	Biological Process	Microtubule-based Movement Protein Transport Post-translational Protein Modification Cellular Protein Metabolic Process	Microtubule-based Movement Cytoplasm Organization Axon Guidance Hippocampus Development Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Vesicle Fusion Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Interferon-gamma Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Intracellular Protein Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Voltage-gated Sodium Channel Activity Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)	Anti-saccade response ( 29064472) Bipolar disorder with mood-incongruent psychosis ( 23092984) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycine levels ( 30837465) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		29 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 IKBKE KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 MFSD14B PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG SGTA SIRPA STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I	36 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		3895	3799
HPRD ID		02661	07214
Ensembl ID		ENSG00000126777	ENSG00000170759
Uniprot IDs		A0A024R663 Q86UP2	P33176 Q6P164 V9HW29
PDB IDs			1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ
Enriched GO Terms of Interacting Partners?
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