PEDS1-UBE2V1 and CNR2

Data Source:
BioGRID (two hybrid)

		PEDS1-UBE2V1	CNR2
Description		PEDS1-UBE2V1 readthrough	cannabinoid receptor 2
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GO Annotations	Cellular Component		Cytoplasm Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perikaryon
	Molecular Function		G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding
	Biological Process		Response To Amphetamine Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Metabolic Process Sensory Perception Of Pain Leukocyte Chemotaxis Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Dronabinol Nabilone Ricinoleic Acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS			Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Psychotic experience (distressing) ( 31553412)
Interacting Genes		17 interacting genes: AQP6 CNR2 CREB3L1 FAM209A GPR152 PGRMC2 SLC10A1 SLC10A6 SLC18A3 SLC30A4 STOM TMEM31 TMEM52B TMX2 TRAF6 TRHR UBE2N	24 interacting genes: ADAM21 ADIPOQ AGPAT4 CCL4 COMT FXYD3 GNA15 MUC15 NRM PEDS1-UBE2V1 RFT1 SELENOK SLC35E4 SLC39A2 TMEM19 TMEM203 TMEM242 TMEM60 TMEM86A TMPPE TSPO2 YIPF1 YIPF4 YIPF6
Entrez ID		387522	1269
HPRD ID		11926	05444
Ensembl ID		ENSG00000124208	ENSG00000188822
Uniprot IDs		A5PLL7 Q13404	A0A024RAH7 P34972
PDB IDs		2A4D 2C2V 2HLW 6D6I	2KI9 5ZTY 6KPC 6KPF 6PT0
Enriched GO Terms of Interacting Partners?
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