TNPO1 and RPL23A

Data Source:
HPRD (in vitro)

		TNPO1	RPL23A
Description		transportin 1	ribosomal protein L23a
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cilium Extracellular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Cytosolic Large Ribosomal Subunit Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding Cadherin Binding TORC2 Complex Binding
	Biological Process	Protein Import Into Nucleus Viral Process Intraciliary Transport Involved In Cilium Assembly Regulation Of MRNA Stability	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription
Pathways		Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Intraflagellar transport Postmitotic nuclear pore complex (NPC) reformation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin Artenimol
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Factor VIII levels ( 30586737) Height ( 31562340) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 32888494 28957414) Serum albumin level ( 29403010) vWF levels ( 30586737)	Total cholesterol levels ( 30275531)
Interacting Genes		18 interacting genes: ELAVL1 H2BC21 H3-4 HNRNPA1 HNRNPD NUP153 NUP214 NUP98 NXF1 PABPN1 RAN RANBP2 RGPD5 RPL23A RPL5 RPS7 SRP19 ULK2	7 interacting genes: CTPS2 DUX4 IPO5 IPO7 NAP1L1 PTEN TNPO1
Entrez ID		3842	6147
HPRD ID		04210	15998
Ensembl ID		ENSG00000083312	ENSG00000198242
Uniprot IDs		A0A024RAM0 Q92973	P62750
PDB IDs		1QBK 2H4M 2OT8 2QMR 2Z5J 2Z5K 2Z5M 2Z5N 2Z5O 4FDD 4FQ3 4JLQ 4OO6 5J3V 5TQC 5YVG 5YVH 5YVI	4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SXO 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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