TNPO1 and ELAVL1

Data Source:
HPRD (in vitro, in vivo)

		TNPO1	ELAVL1
Description		transportin 1	ELAV like RNA binding protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cilium Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity
	Biological Process	Protein Import Into Nucleus Viral Process Intraciliary Transport Involved In Cilium Assembly Regulation Of MRNA Stability	MRNA Splicing, Via Spliceosome Protein Import Into Nucleus Posttranscriptional Gene Silencing Regulation Of MRNA Stability Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Intraflagellar transport Postmitotic nuclear pore complex (NPC) reformation	HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Factor VIII levels ( 30586737) Height ( 31562340) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 32888494 28957414) Serum albumin level ( 29403010) vWF levels ( 30586737)	Blood protein levels ( 28240269)
Interacting Genes		18 interacting genes: ELAVL1 H2BC21 H3-4 HNRNPA1 HNRNPD NUP153 NUP214 NUP98 NXF1 PABPN1 RAN RANBP2 RGPD5 RPL23A RPL5 RPS7 SRP19 ULK2	37 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VCP VEGFA XIAP
Entrez ID		3842	1994
HPRD ID		04210	16025
Ensembl ID		ENSG00000083312	ENSG00000066044
Uniprot IDs		A0A024RAM0 Q92973	Q15717
PDB IDs		1QBK 2H4M 2OT8 2QMR 2Z5J 2Z5K 2Z5M 2Z5N 2Z5O 4FDD 4FQ3 4JLQ 4OO6 5J3V 5TQC 5YVG 5YVH 5YVI	3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?
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