KPNA5 and HNRNPC

Data Source:
BioGRID (two hybrid)

		KPNA5	HNRNPC
Description		karyopherin subunit alpha 5	heterogeneous nuclear ribonucleoprotein C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Splicing RNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase ATP-dependent Chromatin Remodeling 3'-UTR-mediated MRNA Stabilization
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Early cardiac repolarization ( 31600170) Telomere length ( 21460395)	Bipolar disorder ( 31043756 21738484) Height ( 31562340)
Interacting Genes		28 interacting genes: ANP32A ANP32B ARNT BRMS1 CDKN1B DCPS EPAS1 FAM214B FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 NUP50 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326	58 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 EPS8 ERG ESR1 FAS FXR2 GRB2 HNRNPCL1 HNRNPCL2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MEOX2 PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 RBPMS2 RNF4 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I YWHAE YWHAQ ZFYVE26 ZNF581
Entrez ID		3841	3183
HPRD ID		05179	01243
Ensembl ID		ENSG00000196911	ENSG00000092199
Uniprot IDs		O15131	P07910
PDB IDs		4U2X	1TXP 1WF2 2MXY 2MZ1 3LN4
Enriched GO Terms of Interacting Partners?
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