KLK2 and SERPINF2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KLK2	SERPINF2
Description		kallikrein related peptidase 2	serpin family F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Platelet degranulation Dissolution of Fibrin Clot
Drugs			Ocriplasmin Copper
Diseases			Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		3817	5345
HPRD ID		01006	02029
Ensembl ID		ENSG00000167751	ENSG00000167711
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	P08697
PDB IDs		4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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