KCNE3 and C11orf68

Data Source:
BioGRID (two hybrid)

		KCNE3	C11orf68
Description		potassium voltage-gated channel subfamily E regulatory subunit 3	chromosome 11 open reading frame 68
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	RNA Binding Protein Binding
	Biological Process	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole
Diseases		Brugada syndrome (BRS)
GWAS		Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)	Acne (severe) ( 24927181) Asthma ( 31959851)
Interacting Genes		10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1	14 interacting genes: CSDE1 EIF4H KCNE3 KLF15 MEOX2 MTCL1 NONO PHETA1 REL SDCBP SH3GL3 TRAPPC2L ZNF341 ZNF512B
Entrez ID		10008	83638
HPRD ID		07256	12553
Ensembl ID		ENSG00000175538	ENSG00000175573
Uniprot IDs		Q6IAE6 Q9Y6H6	Q9H3H3
PDB IDs		2NDJ 6V00 6V01	1ZTP 2Q4K
Enriched GO Terms of Interacting Partners?
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