Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
USP17L2 and KMT5A
Data Source:
BioGRID
(pull down)
USP17L2
KMT5A
Description
ubiquitin specific peptidase 17 like family member 2
lysine methyltransferase 5A
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum Membrane
Cytosol
Nucleoplasm
Chromosome
Cytosol
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
P53 Binding
Transcription Corepressor Activity
Protein Binding
Lysine N-methyltransferase Activity
Protein-lysine N-methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity (H4-K20 Specific)
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Mitotic Cell Cycle Checkpoint
Negative Regulation Of Protein Processing
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Cell Migration
Negative Regulation Of Histone Deacetylation
Negative Regulation Of GTPase Activity
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Regulation Of Defense Response To Virus By Host
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
CAAX-box Protein Processing
Negative Regulation Of Protein Targeting To Membrane
Regulation Of Ruffle Assembly
Positive Regulation Of MDA-5 Signaling Pathway
Positive Regulation Of RIG-I Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Peptidyl-lysine Monomethylation
Histone H4-K20 Methylation
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Transcription, DNA-templated
Cell Division
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Ub-specific processing proteases
RAS processing
Condensation of Prophase Chromosomes
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
High density lipoprotein cholesterol levels (
29403010
)
Interacting Genes
7 interacting genes:
BRD4
CDK4
CDK6
ELK1
KMT5A
LGMN
SNAI1
11 interacting genes:
BTRC
DTL
E2F2
FAM9A
H4-16
PCNA
TCF7L2
TP53
TWIST1
UBE2I
USP17L2
Entrez ID
377630
387893
HPRD ID
16844
06254
Ensembl ID
ENSG00000223443
ENSG00000183955
Uniprot IDs
Q6R6M4
E3VVS3
Q9NQR1
PDB IDs
1ZKK
2BQZ
3F9W
3F9X
3F9Y
3F9Z
4IJ8
5HQ2
5T5G
5TEG
5TH7
5V2N
5W1Y
6BOZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?