KCNJ8 and KCNJ11

Data Source:
HPRD (in vivo, in vitro)

		KCNJ8	KCNJ11
Description		potassium inwardly rectifying channel subfamily J member 8	potassium inwardly rectifying channel subfamily J member 11
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Myofibril Potassium Ion-transporting ATPase Complex Sarcolemma	Acrosomal Vesicle Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Inward Rectifying Potassium Channel Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Cation Transmembrane Transporter Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding
	Biological Process	Kidney Development Potassium Ion Transport Heart Development Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Response To Exogenous DsRNA Defense Response To Virus Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Potassium Ion Import Across Plasma Membrane	Response To Ischemia Glucose Metabolic Process Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process Transmembrane Transport Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane Positive Regulation Of Cation Channel Activity
Pathways		ATP sensitive Potassium channels	ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben	Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole
Diseases			Type II diabetes mellitus Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Birth weight ( 31043758)	Body mass index ( 26426971 28892062 25673413 29273807) Circulating leptin levels or type 2 diabetes ( 32341051) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 27618448 30578418) Social communication problems ( 24564958) Systolic blood pressure ( 27618448 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 32499647 17463246 30718926 17463248 17463249 28869590 19056611) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54	7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA
Entrez ID		3764	3767
HPRD ID		02962	09022
Ensembl ID		ENSG00000121361	ENSG00000187486
Uniprot IDs		A0A024RAV6 Q15842	B2RC52 Q14654
PDB IDs			6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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