KCNJ8 and ABCC8

Data Source:
HPRD (in vitro)

		KCNJ8	ABCC8
Description		potassium inwardly rectifying channel subfamily J member 8	ATP binding cassette subfamily C member 8
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Myofibril Potassium Ion-transporting ATPase Complex Sarcolemma	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Cation Transmembrane Transporter Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding
	Biological Process	Kidney Development Potassium Ion Transport Heart Development Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Response To Exogenous DsRNA Defense Response To Virus Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Potassium Ion Import Across Plasma Membrane	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		ATP sensitive Potassium channels	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben	ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases			Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Birth weight ( 31043758)	Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54	5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		3764	6833
HPRD ID		02962	02741
Ensembl ID		ENSG00000121361	ENSG00000006071
Uniprot IDs		A0A024RAV6 Q15842	Q09428
PDB IDs			6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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